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MSO irreversibly inhibits the astrocytic enzyme glutamine synthase (GS) but also interferes with the transport of glutamine (Gln) and of glutamate (Glu), and -aminobutyric acid (GABA) synthesized within the Glu/Gln-GABA cycle, in this way dysregulating neurotransmission balance in favor of excitation

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Nat Commun 11, 3796 Barutaut, M., Fournier, P., Peacock, W.F., Evaristi, M.F., Caubere, C., Turkieh, A., Desmoulin, F., Eurlings, L.W.M., van Wijk, S., Rocca, H.B., Butler, J., Koukoui, F., Dambrin, C., Mazeres, S

doi: 10.3797/scipharm.1408-16 166 NeagMAMocanAEcheverriaJPopRMBocsanCICrisanGet al

Lyophilized powder tolerates brief ambient exposure better than reconstituted solution, but both degrade rapidly outside cold storage

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