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In various cell lines, bupivacaine has been reported to hinder the functions of mitochondrial respiratory chain complexes I and III [102], potentially inducing excessive activation of mitochondrial mPTP channels [103], which can lead to mitochondrial depolarization and cell apoptosis [104]

8c, S9c)

a, c , d, e, n = 3 biologically independent samples

This is significant because NLRP3 may contribute to the pathogenesis of atherosclerosis through a signalling pathway that triggers PCSK9 secretion via IL-1 stimulation (86)

Importantly, dietary interventions targeting oocyte quality are guided by follicular fluid fatty acid composition analyses, which reveal elevated levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Kermack et al., 2021)