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Future research should focus on novel biomarker development to identify patients most likely to benefit from these targeted strategies

FOXP3, Forkhead box protein P3
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From each subject, a detailed brain image was first acquired, using a magnetization-prepared rapid gradient echo 47 high-resolution T1-weighted sequence (repetition time=6.6 ms, echo time=3.0 ms, flip angle=8, matrix=256240, slices =170, and slice thickness=1 mm)

The pathogenic causes of ALS are complex and include OS, which causes mitochondrial dysfunction and motor neuron loss