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Overall, structural alterations found in SURF1 and other LS mutant organoids confirmed the dysregulation of NPCs function and morphogenesis as a relevant mechanism in the pathophysiology of LS
MT binding to cisplatin can induce drug resistance, which can be reversed by short hairpin MT (shMT) [34]
Synthesis of GSH and de novo lipids occurs in the liver
Based on the evolutionary analysis, we were able to classify most of the TmGsts into the known Gst class with high bootstrap values
A novel GAA-repeat-expansion-based mouse model of Friedreichs ataxia
