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Graphical abstract The above scientific illustration shows that, after intracellular polyglutamylation, Methotrexate induces oxidative stress in hepatocytes
18 No similar improvement was observed in a human trial looking at depression
voxel size: 0.45 mm 0.45 mm 4 mm)
This led to the development of compounds irreversibly interacting with EGFRm/T790M, such as afatinib, 324674 and more recently AZD9291 and CO1696 [1012]
[DOI] [PMC free article] [PubMed] [Google Scholar] 48.He C., Klionsky D.J
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