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However, when it is highly activated, it might lead to the inhibition of tumor growth [66]

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These alterations may be further exacerbated by oxidative stress and activation of profibrotic cytokines, such as transforming growth factor , ultimately contributing to the development of chronic kidney disease (82)

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Taken together, the effective non-surgical treatment for PD should be combination modality, including various pharmacotherapies, mechanical therapies, shock wave therapies, psychotherapies, and so on, which might generate synergy benefits to PD patients

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