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If you have symptoms that suggest vitamin B12 deficiency such as numbness tingling or anemia you must do a blood test to evaluate how much vitamin B12 is in your blood to properly diagnose it

B12 is a cofactor for succinyl-CoA synthesis and for the conversion of homocysteine to methionine

M.DragoF.SalomoneS
An endogenous supply is theoretically possible, but only with extremely good intestinal health