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Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production

418,419 Although research on the pathophysiological mechanisms of DN covers multiple aspects, several pathways remain poorly understood, and the clinical application of treatment strategies remains limited

8.1.7 Endogenous metabolites Basheer et al

J Huazhong Univ Sci Technolog Med Sci 25:501504

doi:10.1007/s12029-012-9441-y Jeurnink SM, Ros MM, Leenders M, et al

Common variants of the PYROXD2 gene are associated with small increases of TMA in urine [21], and it is logical to assume that variants exist that might be more disruptive and have commensurately greater effects on TMA accumulation
