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Disease Prevention Esophageal cancer Linxian is a small region in northern China where the incidence of cancer of the esophagus and stomach is very high (10 times higher than the average in China and 100 times higher than the average in the US)

[PUBMED Abstract] Saarinen-Pihkala UM, Heilmann C, Winiarski J, et al.: Pathways through relapses and deaths of children with acute lymphoblastic leukemia: role of allogeneic stem-cell transplantation in Nordic data

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However, compared to that in non-malignant tissues, the expression level of GPx1 in tumor tissues was significantly decreased by 7.4% [83]

These results have led to a focus on epimutation as a novel oncogenic mechanism [26]

doi: 10.1021/acsbiomaterials.0c01126