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Description
10.3760/cma.j.issn.0578-1310.2017.08.017(in Chinese)
Inflammation modulation in injury models
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GC35139 4-Methylesculetin 4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities
What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis
Accessed December 15, 2013
