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10.1152/ajpcell.00001.2016 10 FreitasR.MartinsA.SilvaJ.AlvesC.PinteusS.AlvesJ.et al (2020)

Vitamin B12 is generally very safe even at high doses because it is water-soluble and excess amounts are excreted in urine

This is the same directional change sought with FDA-approved therapies like minoxidil, but achieved through a distinct upstream mechanism
