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A recent study by Li Ge et al used a DSS model to investigate the specific effects of hydrogen molecules on gut microbiota homeostasis and the anaerobic environment

The need for a cold chain makes their global distribution and application logistically difficult and for under-developed and developing nations with tropical climates, nearly impossible

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doi: 10.2337/dc19-0167 [DOI] [PubMed] [Google Scholar] 99

**BPC-157, a synthetic gastric pentadecapeptide studied primarily in animal models for tissue repair, gut healing, and anti-inflammatory effects, remains unapproved by the FDA as a finished drug with only limited small-scale human data available.** It was placed in Category 2 in 2023 due to concerns over immunogenicity, peptide impurities, and insufficient safety information for compounding under Section 503A