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One possible mechanism is increased oxidative stress leading to altered neurodevelopment and brain function

Alcohol is a particular concern, as it's thought to substantially lower the body's levels of this antioxidant

doi: 10.1016/j.clnesp.2019.03.015 [DOI] [PubMed] [Google Scholar] [149].Bobe G, Michels AJ, Zhang W-J, et al

[3] An editorial in Thyroid , written by Peter Andreas Kopp in 2014, found that patients remain symptomatic (that is, they may experience symptoms like fatigue) despite having normal thyroid hormone levels

10.1056/nejmoa010107 2 AllardJ

However, their elevated concentration, affects the cell by causing cellular injury, eventually leading to PCD