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The evidence in this review found that there is probably no difference between PDE and alpha blockers, however when used in combination they may provide a greater improvement in symptoms (with more side effects)

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10.1126/science.aaf1644 [Google Scholar] Vaiserman A, Krasnienkov D (2021) Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives