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How Vitamin B12 Affects Brain Chemistry and Stress Systems Neurotransmitter production B12, together with folate and B6, is essential for the methylation reactions that produce serotonin, dopamine, norepinephrine, and GABA the neurotransmitters most directly involved in regulating mood, motivation, calm, and emotional stability

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NCOA4 is an autophagic component involved in the autophagic process of iron proteins FTH1 and FTL, capable of degrading iron proteins, releasing ferrous iron, and promoting cell ferroptosis

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