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Abstract Background Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER)
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In 2021, McConnell et al
Small-study effects were examined via funnel plots, Eggers regression, and Beggs rank test, with trim-and-fill used as sensitivity analysis when indicated
GLUT3 is a high affinity transporter (low Km) that initially was thought to be only present in neuronal cells, but now has been found in sperm, embryos, and leukocytes (Mueckler, 1994
References: 1 WHO
