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In older adults, GlyNAC supplementation upregulated markers of mitochondrial biogenesis and energy metabolism, improved intercellular communication, as well as down-regulated of HOMA-IR, fasting insulin, and (pAMPK)/AMPK and thus indicating alterations of nutrient sensing

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Peptide integration: BPC-157 or Thymosin Beta-4 starting 1-2 weeks pre-surgery continuing 4-8 weeks post-operatively

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FIGURE 5 In summary, metformin demonstrates limited efficacy in the prevention of EC associated with PCOS