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Nutrients 2016, 8 (1)

The pink color (malondialdehyde) was measured at 535 nm against blank (distilled water instead of sample)

& Katsura, I

Intracranial injection (5 10 4 MG3 cells in 1 L) performed under stereotactic guidance, 2 mm deep into the brain parenchyma aiming for subcortical white matter, using a Hamilton syringe at a flow rate of 0.25 L/min

doi: 10.3389/fimmu.2020.01340

FIGURE 9 Discussion Hyperglycemia-induced chronic inflammation and metabolic dysregulation play a crucial role in the micro- and macro-vascular complications of diabetes and are associated with long-term dysfunction of various organs, especially the liver and kidneys ( Despite the benefits of pharmacological therapies, prophylactic approaches such as physical exercise, besides caloric restriction are considered the cornerstone in the management of type 2 diabetes ( Our previous study in GK rat pancreas demonstrated exercise-induced beneficial effects by improving energy metabolism, antioxidant responses and mitochondrial functions, and metabolic adaptation ( via the AMPK/SIRT-1/PPAR- signaling pathways