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Description
Given the similarities in mucus barriers across different organs, inhalable drug delivery may explore and try to apply strategies used in the gastrointestinal and vaginal mucus to enhance diffusion and retention in the airway 284,285,286,287,288

[PubMed: 4361710] 595

This is due to the models ability to resemble more closely the organotypic histomorphology and microenvironment of hepatocytes in the liver in vivo (Lv et al., 2017), the impact of metabolic cooperation between different cell types on metabolic profiling and long-term survival being metabolically competent

This enrichment is crucial for maximizing the likelihood of detecting therapeutic effects and for avoiding the inclusion of patients unlikely to benefit from the intervention
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