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Dihexa works by binding to the HGF receptor c-Met on hippocampal neurons, activating intracellular signaling pathways that increase synaptogenesis, dendritic spine density, and NMDA receptor expression

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In older adults, a diagnosis of osteopenia or osteoporosis is made based on a decrease in BMD relative to normal peak BMD levels, whereas in younger people, these diagnoses are made based on comparisons to normal BMDs for age

doi: 10.1016/j.bmc.2009.02.043