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Nitric Oxide Biol Chem 99:716
To further confirmed that TXNDC12 inhibits PAAD cell ferroptosis via GSH metabolism, we used the GSH synthesis inhibitor BSO (PANC-1 1.53 mM, MIA PaCa-2 3.506 mM) and exogenous GSH 500 M to incubate the cells and detected changes in the content of GSH and GSSG while knocking down TXNDC12
doi: 10.1111/jnc.13593 178 DayJOMullinS
This difference may be explained by the results of in vitro binding studies, which showed that daratumumab can directly bind CD38 on RBCs, whereas isatuximab requires a cofactor (e.g., a mouse anti-CD38 antibody or a CD38 inhibitor), suggesting masking of the isatuximab epitope on RBCs in some patients [49, 50]
As mentioned previously, a defect with the MTHFR gene can cause an abnormally high level of homocysteine in the blood
