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In summary, there are several topical therapeutic approaches aimed at targeting oxidative stress in DED include the reduction of inflammation and the enhancement of antioxidative defense mechanisms

Huang and colleagues discovered a compound, 43 , with potent inhibitory activity, exhibiting an IC 50 value of 0.13 M, against the drug allopurinol and febuxostat, with IC 50 values of 2.93 and 0.01 M, respectively