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Exercise modalities range widely across investigations, including concurrent training in postmenopausal women (Samadpour Masouleh et al., 2021), and multicomponent protocols in sarcopenic obesity (Ortiz et al., 2025)

In summary, RCTs remain essential for establishing efficacy and internal validity, but their limited generalizability, high cost, and ethical constraints restrict their ability to answer all questions relevant to patient care

doi: 10.7150/ijms.17860 166 BhatVOlmerMJoshiSDurdenDLCramerTJBarnesRFet al

Gastroenterology (2008) 134:688

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