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STING, a critical cellular defense in promoting immune resistance to microbial pathogens and cancers, is activated by the presence of cytosolic DNA or cyclic dinucleotides (CDNs) within the cell cytoplasm [36]

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Mammalian Polyamine Metabolism and Function

Indeed, all these transition metals are essential trace elements for humans

(95% CI: 0.56 to 0.75)
