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Most significant effect on tumor responses was achieved by immunotherapy or targeted therapy using small-molecule drugs and monoclonal antibodies so far

Secondary antioxidants serve as scavengers for ROS

In 2007 an uncontrolled study examined the efficacy of nebulized colistin in a mixed population of patients with COPD and bronchiectasis colonized with PSAE and showed an improvement in quality of life and slower decline with FEV1 with treatment.85 Currently, many other clinical trials are being carried out with the purpose of establishing the indications for inhaled antibiotic therapy in these patients and define which antibiotics to use and the most appropriate devices to deliver them.86 In fact, at the moment, the clinical evidence that supports the use of chronic inhaled antibiotherapy in non-CF BE, chronically colonized with Pseudomonas, is scarce but all the data suggest that this therapeutic strategy seems to control the symptoms, prevent the progression of the disease and reduce the morbidity with no relevant adverse events.87,88 The chronic antibiotherapy may be intermittent (28 days on, 28 days off) when using tobramycin or aztreonam lysine or continuous when using sodium colistimethate

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p53-independent roles of MDM2 in NF-B signaling: implications for cancer therapy, wound healing, and autoimmune diseases

[DOI] [PubMed] [Google Scholar] 141.Frost DA, Soric MM, Kaiser R, et al