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559 Administering small molecule ferroptosis inhibitors improves neurodegeneration in GPX4BIKO mice, indicating ferroptosis may play a crucial role in the pathology of AD

For example, midazolam has been found to lack neuroprotective effects on brain tissue damage following trauma

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The animal study protocol was approved by the Ethics Committee from Escuela Nacional de Ciencias Biolgicas del Instituto Politcnico Nacional (under registration number ENCB/CEI/085/2023 CONBIETICA-09-CEI-00220190327, on 15 April 2023) for studies involving animals and El Colegio de la Frontera Sur under registration number CEI/2023/3798/05, on 5 January 2023)

We confirmed that condensin genes were not significantly affected by Pmc4 depletion

PDTAC: targeted photodegradation of GPX4 triggers ferroptosis and potent antitumor immunity