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Up to 80% of cirrhosis patients report poor sleep quality, as evidenced by Pittsburgh Sleep Quality Index (PSQI) scores exceeding 5 (ChildTurcottePugh [CTP] A: 16.9%, CTP B: 26.5%, and CTP C: 56.6%), and around 16 to 52% suffer from excessive daytime sleepiness (EDS), reflected by Epworth Sleepiness Scale (ESS) scores over 10 (CTP A: 17.6%, CTP B: 29.7%, CTP C: 52.8%) ( Insomnia, defined as difficulty initiating or maintaining sleep, is chiefly diagnosed through patient-reported symptoms

Alternatively, when cancer cells use GSH as a cysteine source, they rely less on these pathways (that is, xCT and TXNRD1)

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[DOI] [PubMed] [Google Scholar] 91.Hernndez-Ortiz N, Snchez-Murcia PA, Gil-Campillo C, Domenech M, Lucena-Agell D, Hortigela R, Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents

34: Selenium