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2021 Dec 11;398(10317):2160-2172

The release of 5-HETE, 11-HETE (but not 12-HETE), and 15-HETE has been observed following ferroptotic stimuli and treatment of cells with 5-HpETE, 12-HpHETE, and 15-HpHETE accelerates the ferroptotic process
Each of the compounds transported by the SMVT is competitive with the others
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But oxidation by cytochrome P450 enzymes is one of the most common forms of bioactivation, resulting in toxic drug metabolites that can bind to cellular macromolecules such as proteins, lipids, or DNA, initiating cellular damage, inflammation, or even carcinogenesis
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