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In sequences containing Asp-Pro, the cyclic imide formation can actually cleave the peptide backbone entirely, splitting the peptide into two fragments
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the dosage is preferable in the range from 10 -5 to 10 -2 mg/kg of body weight, applied systemically or topically in higher concentration between 0.1% to 0.5%
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The mechanisms behind the therapeutic activity of BET bromodomain inhibition
