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The oxidation of fatty acids inhibits glucose oxidation as outlined in the above figure

& Spapen, H

10.1126/science.277.5329.1094

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These studies suggest that low circulating IGF-I bioactivity and/or abnormalities of IGF-I signaling in elderly subjects, may play an important role in age-related sarcopenia and osteopenia, where the substitutive IGF-I treatment may be a suitable therapeutic strategy, although this apparent IGF-I resistance may dampen this aim

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