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Mitochondrial dysfunction is characterized by various degrees of ultrastructural mitochondrial damage, abnormal morphologic changes, increased permeability of the outer and inner membranes, impaired mitochondrial -oxidation, respiratory chain activity reduction, ROS overproduction, ATP depletion, and oxidative stress-mediated deletions of mtDNA inducing apoptosis (Ramanathan et al

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[DOI] [PubMed] [Google Scholar] 105.Ruzzolini J., Peppicelli S., Bianchini F., Andreucci E., Urciuoli S., Romani A., Tortora K., Caderni G., Nediani C., Calorini L

48 , who reported that NAFLD and nonalcoholic steatohepatitis (NASH) patients' livers had significantly greater levels of LPL messenger RNA (mRNA) expression than did healthy subjects' livers