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This makes primer dilution simple once the relationship is understood

Brain-to-plasma exposure metrics, such as K p, brain , may provide a useful measure of total brain exposure relative to systemic exposure, while K p, uu, brain , where feasible, may offer a more informative assessment of unbound brain exposure at the BBB

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Patients arrive with tendon injuries that have not responded to physical therapy, gut issues that antibiotics made worse, and joint inflammation that has been managed but never resolved
