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IglayKHannachiHJoseph HowiePXuJLiXEngelSSet al

Zepbound (tirzepatide) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

(70) confirmed that elevated LPS in PCOS mice can reach the ovaries and be recognized by macrophages, activating intracellular caspase-11 to initiate a cascade reaction of pyroptosis, leading to the cleavage of the pyroptosis execution protein Gasdermin D (GSDMD) into its active N-terminal fragment (GSDMD-N)

doi: 10.1016/j.neulet.2006.09.070

l-Carnitine reduced the number of LC3 green puncta but increased the number of GFP-negative/RFP-positive puncta, which are displayed in red because of the elimination of the blockade of autophagic flux in PFOS-treated RTCs