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231 Mechanistically, ketones produced by liver metabolism act as both energy supply molecules and signal molecules involved in binding G protein-coupled receptors, inhibiting HDACs, regulating the abundance of intestinal microbiota, improving intestinal barrier function, and reducing the production of ROS and free radicals

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A summary of the different treatment options, divided across pharmacological and non-pharmacological treatments, can be found in Table 1

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Exogenous antioxidantsDouble-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses