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Comparison with biochemical changes in demyelinating plaques

For example, L-theanine has been shown to reduce oxidative stress by increasing total antioxidant capacity, GSH, and superoxide dismutase [121, 122] and to protect against DA-induced neurotoxicity via boosting GSH levels [123]

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423 Vaccine-based approaches, including dendritic cell therapies and polyepitope constructs such as STEMVAC, continue to face immunogenicity and scalability hurdles, including patient-specific antigen selection, ex vivo manipulation, and low durability of response