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Systemic Detoxification: Uses powerful antioxidants to neutralize free radicals and reduce systemic inflammation, which is often the precursor to chronic illness

doi: 10.3389/fpls.2018.01957 108 MewaD

Trx, glutaredoxins (class I and class II), and Prx display overlapping and different functions

Abbreviations ASD: Autism spectrum disorder C1: One-carbon CFD: Cerebral folate deficiency CNS: Central nervous system DA: Dopaminergic FOLH1: Folate hydrolase 1 FR: Folate receptor FR: Folate receptor FR: Folate receptor FR: Folate receptor FRAAs: Folate receptor autoantibodies bFRAAs: Blocking autoantibodies to folate receptor GPI: Glycosylphosphatidylinositol MTHFR: Methylenetetrahydrofolate reductase 5-MTHF: 5-Methyltetrahydrofolate NMDA: N-methyl-D-aspartate Pax3: Paired box 3 PCFT: Proton-coupled folate transporter RFC: Reduced folate carrier SCF: Cerebrospinal fluid TRP/TRPM: Transient receptor potential superfamily, melastatin-related subfamily References Saitsu H (2017) Folate receptors and neural tube closure