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PMID: 112

Li Z, Zhao P, Zhang Y, Wang J, Wang C, Liu Y, et al

The paracellular pathway is considered the dominant transport mechanism based on animal studies

Genetic analysis confirmed SETX gene mutations in five patients, including three novel mutations, while the remaining three had APTX gene mutations with one novel variant

They can kill the microorganism by inhibiting the synthesis of nucleic acid (DNA and RNA) and proteins, proteins from functioning, cell wall formation, intercalating DNA, disrupting cell membranes, and activating autolysis