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Additionally, C/EBP modulates antioxidative defense mechanisms by regulating NAD(P)H quinone oxidoreductase 1 (NQO1) and glutathione S-transferase pi 1 (GSTP1), protecting GBM cells from oxidative stress

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(1984) The cytotoxicity of some organic solvents

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Subsequent studies revealed lower dose (2 mg/m 2 ) GO was tolerable and could be safely added to a RIC regimen, with just 1 out of 44 patients experiencing reversible VOD, 82% showing treatment response at the lower dose and median OS was 11 months [66]

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Therefore, targeting tumor glutaminolysis and c-Myc-induced-glutamine addiction is a promising anti-cancer metabolism therapy

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