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The alkaline environment of the cytoplasm leads to histone acetylation, gene expression and increased protein synthesis, whereas the acidic conditions in the TME contribute to maximal P-gp catalytic activity (Assaraf et al., 2019)
doi:10.3892/mmr.2015.3707 67
D., Leonardo, C
Boerke, A
Rep 16, 45
4a,b), albeit there was no obvious increase in cytoplasmic accumulation of FUS/TLS (Supplementary Fig
