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We hypothesize that the lactate-H3K18la epigenetic axis, the TREM2-SHP1-BTK signaling pathway and itaconate-mediated mitochondrial modulation regulatory nodes in sepsis can function as synchronous elements rather than isolated metabolic changes (25,68,189,190)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.FDA