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These changes, along with its protein expression, significantly correlate with an increase in microvessel density, indicating that aberrant ubiquitination of HIF-1 may be linked to invasion and metastasis of VHL-deficient tumors[60]

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References: Alzoubi KH, Bayraktar E, Khabour O, Al-Azzam SI. Vitamin B12 protects against DNA damage induced by hydrochlorothiazide. Saudi Pharm J. 2018;26(6):786-789. doi:10.1016/j.jsps.2018.04.005

Subsequently, the biotin group in these labeled peptides will be cleaved off by either enzymes (isoTOP-BPP approach) or UV (QTRP and DiaAlk approaches) at a specific wavelength, allowing labeled peptides to be readily analyzed by LC-MS/MS (see Figure 6)

Curcumin has been utilized for an extensive period to address issues regarding the gastrointestinal tract, liver, respiratory system, and sinusitis