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Description
549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons

Michael Conlon describe the scope of it: In clinical trials, CagriSema has achieved greater effects than either component [cagrilintide or semaglutide] alone
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Labs to run: CRP (inflammation), fasting glucose (peptides rarely affect but baseline helps), CMP for liver enzymes

Zepbound is approved for obesity and for OSA with obesity
