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This is known in functional medicine as the "NAC Paradox." While NAC provides the raw cysteine needed for the body to build its own glutathione, clinical observations indicate that NAC can act as a direct histamine liberator in sensitive individuals

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The Therapeutic Use Exemption Program It should be noted that athletes who have a legitimate medical reason for using a prohibited substance or method that is on the List can apply for a Therapeutic Use Exemption (TUE) to determine whether they meet the criteria outlined in the International Standard for Therapeutic Use Exemptions (ISTUE)