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TB-500 is a synthetic fragment of TB4 that is also found on the peptide market

In addition, S -nitrosylation on Cys498 residue of Src kinase induces autophosphorylation, which promotes nitric oxide-mediated cell invasion and resistance to anoikis in cancer cells (68, 69)

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This is self-explanatory

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While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers