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Mitochondrial NAD kinase, overexpressed in many cancers, converts NAD + to NADP + , consuming ATP (Rather et al

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However, individual supplementation of FA did not show positive effects in this study

The main target for Grx2 in mitochondria is Complex I, although UCP3 and the 2-oxoglutarate dehydrogenase (OGDH) have been also shown to be deglutathionylated by Grx2

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Clinical and experimental evidence has consistently demonstrated a robust association between hyperlactatemia and anemia, indicating a functional interconnection between lactate metabolism and systemic iron homeostasis (60)