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Increased toxicity : Grapefruit juice can inhibit enzymes that normally clear drugs, leading to higher blood levels and greater side effects of certain chemotherapy and hormonal agents

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Peptide solutions, dissolved in sterile saline, were mixed with Freunds complete adjuvant (CFA) for the first injection, or Freunds incomplete adjuvant (IFA) for the three subsequent injections

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Summarizing the available data from animal studies, we can conclude that oxidative damage of the brain during treatment with typical antipsychotics is due to the following mechanisms: A significant decrease in the activity of Mn-SOD, Cu,Zn-SOD, and catalase Increased lipid peroxidation of membranes Reduction of NO concentration [345] Increased production of superoxide and H 2 O 2 [345] Human studies also indicate that antipsychotics contribute to oxidative stress [346]