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Vitamin B12 is also needed to help prevent megaloblastic anemia, which is a blood condition that often makes individuals tired and weak

Upregulation of FcRn is primarily associated with stimulation via tumor necrosis factor (TNF), while other pathways have been identified in non-human models

People who consume diets free of animal products as well as those who have pernicious anemia (i.e., malabsorption) are at a greater risk of developing vitamin B12 deficiency

A key study showed that this intervention improved insulin sensitivity in mice, suggesting it helps restore metabolic flexibility

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in its active form (thiamine diphosphate), it is an essential cofactor for enzymes in glucose and amino acid catabolism, helping convert nutrients into ATP and supporting normal neuronal function