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However, whether excess hemin exposure from the hemolysis in SCD will affect CBS expression and the generation of GSH in oxidative and ferroptosis stress response has not been investigated

Angiogenesis initiated from Tumor activated-endothelial cells (TECs), resulting in the production of vascular endothelial growth factor A (VEGF-A), angiopoietin-like 4 (ANGPTL4), placental growth factor (PIGF), and platelet-derived growth factor B (PDGF-B), all of them, contribute to the endothelial cell proliferation, migration, and capillary formation

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The ETC is made up of four protein complexes that transfer electrons from NADH and FADH2 to molecular oxygen, producing a proton gradient across the mitochondrial membrane

doi: 10.1208/s12248-016-9875-4

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