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Given the multifactorial nature of PCOS, therapeutic approaches require personalized strategies rather than single-modality interventions

Mutant mice also show craniofacial and limb deformities, which were later attributed to an essential role for Flvcr in sensory neuron maintenance and T cell development (98)

Wong TL, Kong Y, Ma S

Chen KG, Lacayo NJ, Durn GE et al (2002) Preferential expression of a mutant allele of the amplified MDR 1 ( ABCB 1) gene in drug-resistant variants of a human sarcoma

1 Introduction Solid tumors are made up of tumor cells and the tumor microenvironment (TME) that includes various cells (immune cells and mesenchymal cells) and extracellular matrix (ECM) (1, 2)