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The multifaceted impact of IF on the gut microbiome axis highlights its potential as a sustainable, non-pharmacological intervention for managing gastrointestinal and metabolic disorders [80,81,82] (Table 3)

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Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Engen et al., 2020) (Figure 10)

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